Linda M. Hendershot

linda.hendershot@stjude.org
www.stjude.org/faculty/0,2512,407_2030_4126,00.html  

CV

• 1978-83 NIH Predoctoral Trainee, University of Alabama at Birmingham, Birmingham, AL (1981-1983 completed at the University of Chicago)
• 1983-85 Postdoctoral Fellow, Cellular Immunobiology Unit, University of Alabama at Birmingham, Birmingham, AL
• 1985-87 Instructor, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL
• 1987 Research Assistant Professor, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL
• 1987-92 Assistant Member, Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN
• 1989-95 Assistant Professor (Affiliated) Department of Biochemistry, University of Tennessee, Memphis, TN
• 1992- Associate Member, Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN
• 1995- Associate Professor (Affiliated) Department of Biochemistry, University of Tennessee, Memphis, TN
• 2002- Full Member, Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, TN
• 2003- Full Professor (Affiliated), Department of Molecular Sciences, University of Tennessee Health Sciences Center, Memphis, TN

Research Interest

• Control of the synthesis and assembly of secretory proteins in the ER
• Regulation of immunoglobulin transport
• Elucidation of ER stress-induced signal transduction pathways
• Role of the ER stress response in regulating tumor chemosensitivity

Selected Publications

1. Dudek J, Greiner M, Muller A, Hendershot LM, Kopsch K, Nastainczyk W, Zimmermann R. ERj1p has a basic role in protein biogenesis at the endoplasmic reticulum. Nat. Struct. Mol. Biol. 2005 12, 1008-1014.
2. Alder NN, Shen Y, Brodsky JL, Hendershot LM, Johnson AE. The molecular mechanisms underlying BiP-mediated gating of the ec61 translocon of the endoplasmic reticulum. J. Cell Biol. 2005 168, 389-399.
3. Brewer JW, Hendershot LM. Building an antibody factory: a job for the unfolded protein response. Nat. Immunol. 2005 6, 23-29.
4. Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: friend or foe? Nat. Rev. Cancer. 2004 4, 966-977.
5. Shen Y, Hendershot LM. ERdj3, a stress-inducible endoplasmic reticulum DnaJ homologue, serves as a cofactor for BiP's interactions with unfolded substrates. Mol. Biol. Cell 2005 16, 40-50.
6. Ma Y, Hendershot LM. Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress. J. Biol. Chem. 2003 278, 34864-34873.
7. Meunier L, Usherwood YK, Chung KT, Hendershot LM. A subset of chaperones and folding enzymes form multiprotein complexes in endoplasmic reticulum to bind nascent proteins. Mol. Biol. Cell 2002 13, 4456-4469.
8. Vanhove M, Usherwood YK, Hendershot LM. Unassembled Ig heavy chains do not cycle from BiP in vivo but require light chains to trigger their release. Immunity 2001 15, 105-114.
9. Lee YK, Brewer JW, Hellman R, Hendershot LM. BiP and immunoglobulin light chain cooperate to control the folding of heavy chain and ensure the fidelity of immunoglobulin assembly. Mol. Biol. Cell 10, 2209-2219.
10. Hamman BD, Hendershot LM, Johnson AE. BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation. Cell 1998 92, 747-758.