.PLENARY LECTURES

Mary Dallman

Dallman
mary.dallman@ucsf.edu
www.ucsf.edu/neurosc/faculty/neuro_dallman.html

CV
Education: Smith College, BA - Chemistry; Stanford University PhD – Physiology; Post-Doc in Stockholm, UCSF. Employment: Physiology Faculty at UCSF 1970-present. Service: NIH Study Sections; NRC Comm Space Biol & Medicine; NIH Workshops, Working Groups on: Perimenopause, Drug Abuse, Stress & CVD, Alzheimer’s Dis. Assoc. Editorships: Am J Physiol, Endocrinology & Metabolism, Am J Physiol. Reg. Integrative & Comp Physiol; Endocrinology. Ed. Boards: Steroids, J Neurosci, Stress, Mol Psychiatry. Honors: Council - APS Endocrinology & Metabolism; Endocrine Soc; President: Women in Endocrinology, Internat Soc Neuroendocrinology. Fogarty Travel Fellowship, Budapest; MT Jones Prize, British Neuroendocrine Soc; Levine Lectureship, Univ Trier; Lectureship Brain Res Institute, Amsterdam; Lifetime Achievement Award, Int Soc Psychoneuroendocrinology.


Research Interest
Chronic stress has a variety of effects on the organism, including changes in energy balance, behavior and responsivity to new stimuli. These effects of chronic stress are probably mediated in large part by the central corticotropin-releasing factor (CRF) neuronal system and glucocorticoids secreted from the adrenal gland in response to drive from hypothalamic CRF. Moreover, all of these are affected strongly by circadian rhythms. Broadly, our lab studies how these changes effected by both acute and chronic stress occur. Specifically, we are delineating: interaction(s) among hypothalamic nuclei that regulate energy balance; changes in brainstem and limbic system components that alter hypothalamic function in chronically stressed animals; the interaction between gonadal and adrenal cortical hormones on regulation of ACTH secretion and energy balance; and, as an overarching theme, the role of glucocorticoids in all of the above. To pinpoint structures that may mediate recruitment of pathways under conditions of chronic stress, we use Fos-immunostaining to delineate increased neuronal activity; combination of Fos and in situ hybridization for peptide mRNA reveals the activated cell phenotype.


Selected Publications
  1. Dallman, M.F., Warne, J.P., Foster, M.T., Pecoraro, N.C. (2007) Glucocorticoids and insulin both modulate caloric intake through actions on the brain. J Physiol., in press.
  2. Dallman, M.F. (2005) Fast glucocorticoid actions on brain: back to the future. Front. Neuroendocrinol. 26, 103-108.
  3. Warne, J.P., Horneman, H.F., Wick, E.C., Bhargava, A., Pecoraro, N.C., Ginsberg, A.B., Akana, S.F., Dallman, M.F. (2006) Comparison of superior mesenteric versus jugular venous infusions of insulin in streptozotocin-diabetic rats on the choice of caloric intake, body weight and fat stores. Endocrinology 147:5443-5451.
  4. la Fleur, S.E., Houshyar, H., Roy, M., Dallman, M.F. (2005) Choice of lard, but not total lard calories, damps ACTH responses to restraint. Endocrinology 146:2193-2199.
  5. Pecoraro, N., Dallman, M.F., Warne, J.P., Ginsberg, A.B., Laugero, K.D., la Fleur, S.E., Houshyar, H., Gomez, F., Bhargava, A., Akana, S.F. (2006) From Malthus to motive: how the HPA axis engineers the phenotype, yoking needs to wants. Prog. Neurobiol. 79:247-340
  6. Pecoraro, N.C., Dallman, M.F. (2005) c-fos following incentive shifts: expectancy, incredulity and recovery. Behav. Nurosci. 119:366-387.
  7. Pecoraro, N.C., Gomez, F., Roy, M., Dallman, M.F. (2005) Single, but not multiple pairings of sucrose and corticosterone enhance memory and amplify remote reward relativity effects. Neurobiol. Learn. Mem. 83:188-195.
  8. Pecoraro, N., Reyes, F., Gomez, F., Bhargava, A. and Dallman, M.F. (2004) Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress. Endocrinology 145, 3754-3762.
  9. Houshyar, H., Manalo, S., Dallman, M.F. (2004) Time-dependent alterations in mRNA expression of brain neuropeptides regulating energy balance and hypothalamic-pituitary-adrenal activity after withdrawal from intermittent morphine treatment. J. Neurosci. 24:9414-9424.
  10. Dallman, M.F., Pecoraro, N., Akana, S.F., La Fleur, S.E., Gomez, F., Houshyar, H., Bell, M.E., Bhatnagar, S., Laugero, K.D. and Manalo, S. (2003) Chronic stress and obesity: a new view of "comfort food". Proc. Natl. Acad. Sci. USA 100, 11696-11701.
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